Mô tả
PHARMACODYNAMICS
- Specific and long-acting inhibitor of gastrointestinal lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine site of the gastric and pancreatic lipases. The inactivated enzyme is thus unavailable to hydrolyse dietary fat, in the form of triglycerides, into absorbable free fatty acids and monoglycerides.
Elimination
- Fecal excretion of the unabsorbed was the major route of elimination. Approximately 97 % of the administered dose was excreted in surface
- The cumulative renal excretion of total orlistat-related materials was < 2% of the given dose. The time to reach complete excretion (faecal plus urinary) was 3 to 5 days. The disposition between normal weight and obese volunteers, all subject to biliary excretion.
INDICATIONS
- Effective in weight loss, weight maintenance and prevention of weight regains. Treatment with Aslene results in an improvement of risk factors and comorbidities associated with obesity, including hypercholesterolemia, noninsulin dependent diabetes mellitus (NIDDM), Impaired glucose tolerance,hyperinsulinemia, hypertension and in a reduction of visceral fat.
DOSAGE AND ADMINISTRATION
- The recommended an120mg capsule with each main meal (during or up to one hour after the meal). If a meal is missed or contains no fat, the dose of Aslene may be omitted.
- The patient should be on a nutritionally balanced, mildly hypocaloric diet that contains approximately 30% of calories from fat. The daily intake of fat, carbohydrate and protein should be distributed over three main meals.
CONTRAINDICATIONS
- Contraindicated in patients with chronic malabsorption syndrome, cholestasis
Use during pregnancy
- Not recommended for use during pregnancy in the absence of clinical data.
Use during lactation
- Should not be taken during breast-feeding.
STORAGE CONDITION
- Store below 25℃ and away from excessive heat, light and moisture not keep in the bathroom.
KEEP OUT OF REACH OF CHILDREN
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