Zonegran 100mg Tab

Manufacturer
Eisai Pharmaceuticals India Pvt. /Ltd.


Content

• Each capsule/tablet contains 100 /mg of the active ingredient zonisamide, which is a sulfonamide antiseizure medication.
• The formulation may include inactive ingredients such as sunset yellow FCF (E110), allura red AC (E129), and soya oil—patients allergic to sulfonamides, peanuts, or soya should avoid taking it.

• Primary use: To treat partial onset seizures, also called focal seizures, with or without secondary generalization—in adults and in children aged six years and above when used alongside other antiepileptic drugs.
• Monotherapy: Can be used alone in newly diagnosed adults with partial seizures.
• Adjunct therapy: Used in combination with other antiseizure medications in adults—and in children ≥ /6 /years depending on weight-based dosing.

Dosage Guidelines:

• Starting dose (adults ≥ /16 /years): 100 /mg once daily.
• Titration: Increment by 100 /mg every 2 /weeks, based on clinical response and tolerability.
• Typical maintenance range: 100–400 /mg/day (often split into 1–2 doses).
• Max dose: Up to 600 /mg/day in divided doses, though doses above 400 /mg/day offer little additional benefit and carry higher risk of side effects.
• Pediatric & adolescents (≥6 /years): Weight-based start at ~1 /mg/kg/day, titrated weekly or biweekly, not to exceed 500 /mg/day.
• Special populations: Use caution and slower titration in patients with renal or hepatic impairment. In severe organ dysfunction, use may be limited or contraindicated.

Administration Instructions:

• Route: Oral—swallow capsules or tablets whole; do not chew or crush.
• With or without food: Can be taken either way; food does not significantly affect bioavailability, though it may alter absorption rate.
• Consistency: Take at fixed time(s) each day to maintain steady blood levels and efficacy.
• Missed dose: Skip if close to next scheduled dose—do not double up.
• Tapering off: Must be withdrawn gradually under medical supervision—abrupt cessation can lead to increased seizure frequency or other risks